Medically reviewed by Drugs.com. Last updated on May 18, 2020.
It must be so difficult to see your husband struggling with the side effects of the anti-biotics treating MAC. I am tagging a few fellow Connect members who can share their experiences with you and offer support along this journey. Please meet @katemn @PaulaMAC2007 @dianeray @heathert @kwilbur @donnavm @laneyk @e345l and @digmeme.
Side Effects
For the Consumer
Applies to propofol: parenteral injectable emulsion
Warning
Redness, mild itching, or flaking skin on the application site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that your. Nitrofurantoin Capsule Side Effects by Likelihood and Severity COMMON side effects. If experienced, these tend to have a Severe expression. SIDE EFFECTS General. Adverse event information is derived from controlled clinical trials and worldwide marketing experience. In the description below, rates of the more common events represent US/Canadian clinical study results. Less frequent events are also derived from publications and marketing experience in over 8 million patients; there are insufficient data to support an accurate. MAC is treated with a combination of antibiotics that should include at least two drugs, usually clarithromycin or azithromycin, plus ethambutol. Other antibiotics may be added depending on the severity of the case. Unfortunately, all of the drugs used to treat MAC can cause serious side effects that may require treatment with yet other drugs.
Special Alerts:
On May 8, 2020, FDA issued an Emergency Use Authorization (EUA) permitting the emergency use of the unapproved product, Fresenius Propoven 2% (propofol 20 mg/mL) Emulsion 100 mL, to maintain sedation via continuous infusion in patients older than 16 years of age who require mechanical ventilation in an intensive care unit (ICU) setting during the COVID-19 pandemic.
Because Fresenius Propoven 2% (propofol 20 mg/mL) Emulsion has a concentration twice that of the FDA-approved propofol product, there is a risk of unintentional overdose. There are also important differences in the formulation and labeling between the two products. Healthcare providers should review the EUA and the differences between the two products prior to administering Propoven. Documents related to the EUA can be found on the FDA website at [Web], including the most recent letter of authorization ([Web]), a fact sheet on the EUA for healthcare providers ([Web]), and a wall chart outlining the key differences between the two products ([Web]).
Side effects include:
Use for anesthesia or MAC sedation: Bradycardia, arrhythmia, tachycardia, hypotension, hypertension, movement, burning/stinging, pain at injection site, apnea, rash, pruritus.
Use for critical care setting sedation: Bradycardia, decreased cardiac output, hypotension, hyperlipidemia, respiratory acidosis (during weaning).
Very rare (less than 0.01%): Pancreatitis, abdominal cramps[Ref]
Genitourinary
Uncommon (0.1% to 1%): Urinary retention oliguria
Rare (Less than 0.1%): Discoloration of the urine following prolonged use[Ref]
Hepatic
Frequency not reported: Hepatomegaly[Ref]
Hypersensitivity
Rare (0.01% to 0.1%): Anaphylaxis, in some cases with angioedema, bronchospasm, erythema, and hypotension (these reactions have been reported to respond to adrenaline)[Ref]
Local
Common (1% to 10%): Pain during injection (e.g., burning, tingling/slinging)
Very rare (less than 0.01%): Tissue necrosis following accidental extravascular administration
Uncommon (0.1% to 1%): Hives/itching, phlebitis, redness/discoloration[Ref]
Metabolic
Uncommon (0.1% to 1%): BUN Increased, creatinine increased, dehydration, hyperglycemia, metabolic acidosis, osmolality increased
Very rare (less than 0.01%): Metabolic acidosis, hyperkalemia, hyperlipidemia[Ref]
Side Effects For Macrobid
Musculoskeletal
Uncommon (0.1% to 1%): Pain in extremities, trunk pain, whole body weakness, pain in extremities, neck rigidity/stiffness
Very rare (less than 0.01%): Rhabdomyolysis (when administered at doses greater than 4 mg/kg/hour for ICU sedation)[Ref]
Nervous system
Paresthesias (including burning, tingling, stinging) and/or pruritus, usually manifested in the perineal region, were the most frequently recorded adverse reactions in clinical trials. Paresthesias and pruritus generally occurred within 5 minutes after administration of the initial dose and were generally transient and mild to moderate in intensity. The pharmacologic basis of these sensory phenomena is unknown. No pretreatments, including the use of nonsteroidal anti-inflammatory drugs, opioids, or lidocaine, are known to have an effect on or to reduce the incidence of these sensations.[Ref]
Very common (10% or more): Paresthesia (74%), excitation phenomena such as involuntary movements, twitches, tremors, hypertonus, hiccup
Common (1% to 10%): Headache, shivering
Rare (0.01% to 0.1%): Convulsions and seizures of the epileptic type
Very rare (less than 0.01%): Postoperative unconsciousness
Frequency not reported: Involuntary movements[Ref]
Side Effects Maca Pills
Respiratory
Very common (10% or more): Hypoxemia (11%)
Common (1% to 10%): Procedural pain (bronchoscopy), transient apnea, cough, respiratory acidosis during weaning
1. 'Product Information. Propofol (propofol).' Hospira Inc, Lake Forest, IL.
2. 'Product Information. Diprivan (propofol).' Zeneca Pharmaceuticals, Wilmington, DE.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
Side Effects For Macrodantin Tablets
More about propofol
During Pregnancy or Breastfeeding
Consumer resources
Other brands:Diprivan, Propoven
Professional resources
Related treatment guides
MAC is a group of mycobacteria found in the air, water, soil, household dust, food, drinking water (even from treated water systems) and in many animals. These bugs are related to both bacteria and fungi; some are capable of causing serious human illness (tuberculosis and leprosy are caused by mycobacterium, for example). They can enter the body through the lungs or intestines and then spread through the bloodstream.
MAC occurs most frequently among people with HIV/AIDS (although its incidence in that group has been declining) but in rare cases, also infects people who don’t have compromised immunity, including children. According to the CDC, MAC occurs in approximately one out of every 100,000 persons in the United States per year. It isn’t passed from person to person and is probably picked up from the environment, although just how isn’t known. Symptoms include high fever, night sweats, diarrhea, weight loss, abdominal pain, fatigue, weakness, anemia, elevated liver function tests and, sometimes, enlargement of the liver and spleen.
MAC is treated with a combination of antibiotics that should include at least two drugs, usually clarithromycin or azithromycin, plus ethambutol. Other antibiotics may be added depending on the severity of the case. Unfortunately, all of the drugs used to treat MAC can cause serious side effects that may require treatment with yet other drugs. And, because the infection is difficult to eradicate, the antibiotics have to be used long term to prevent further attacks.
In addition to antibiotic therapy, I would recommend trying to increase resistance to infection by boosting daily intake of garlic and medicinal mushrooms (especially shiitake, enoki, maitake, reishi and cordyceps). Your wife might also consult with a practitioner of traditional Chinese medicine to help address her immunity and MAC.